NIH- supported researchers map epigenome of more than 1. News Release. Wednesday, February 1. New maps of the human epigenome may further unravel the complex links between DNA and disease. Much like mapping the human genome laid the foundations for understanding the genetic basis of human health, new maps of the human epigenome may further unravel the complex links between DNA and disease. The epigenome is part of the machinery that helps direct how genes are turned off and on in different types of cells. Researchers supported by the National Institutes of Health Common Fund. The data, available to the biomedical research community, can be found at the National Center for Biotechnology Information website. The NIH Common Fund is hosting a session that will include presentations from several Common. National Institutes of Health The NIH Roadmap Epigenomics Program. Introduction to Roadmap EpiGenome Browser - Duration: 4:13. Welcome to the Epigenome Roadmap! Here, we have collected research papers describing the main findings of the NIH Roadmap Epigenomics Program, the aim of which was to. NIH-supported researchers map epigenome of more than. About the National Institutes of Health. More than 2. 0 additional papers, published in Nature and Nature- associated journals, show how these maps can be used to study human biology. During the development of different types of cells, regulatory proteins turn genes on and off and, in doing so, establish a layer of chemical signatures that make up the epigenome of each cell. The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary. NIH ROADMAP scientists map epigenome of more than 100 tissue and cell types in Nature. February 18, 2015 Researchers from the NIH Common Fund’s Roadmap Epigenomics. NIH Roadmap Reference Epigenome Mapping Consortium genome-wide epigenetic maps in human primary cells and tissues data available, with viewing and analysis options. The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and. NIH Roadmap Epigenomics Program - Broad Institute. The Roadmap Epigenomics Broad cohort is utilized in the following dbGaP sub-study. In the Roadmap Epigenomics Program, researchers compared these epigenomic signatures and established their differences across a variety of cell types. The resulting information can help us understand how changes to the genome and epigenome can lead to conditions such as Alzheimer. These maps are like snapshots of the human genome in action. Common Fund programs are designed to overcome major research barriers and pursue emerging opportunities for the benefit of the biomedical research community at large. The research products of the Common Fund programs are expected to catalyze disease- specific research supported by the NIH Institutes and Centers. NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Reference Epigenome Mapping Centers (U01) RFA-RM-07-013.To learn more about the NIH Common Fund, visit http: //commonfund. NIDA supports most of the world. The institute carries out a large variety of programs to inform policy and improve practice. Fact sheets on the health effects of drugs of abuse and information on NIDA research and other activities can be found at http: //www. Pad, or tablet. To order publications in English or Spanish, call NIDA. Online ordering is available at http: //drugpubs. For more information on environmental health topics, visit http: //www. Subscribe to one or more of the NIEHS news lists to stay current on NIEHS news, press releases, grant opportunities, training, events, and publications. About the National Institutes of Health (NIH). NIH, the nation's medical research agency, includes 2. Institutes and Centers and is a component of the U. S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www. NIH. Integrative analysis of 1. Nature; doi: 1. 0.
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Fortunately, things didn't rest on me alone. It hasn't always been easy to walk the fine line between. It was at the end of one of these talks (at a convention in Missoula. Montana), just as I described some rules change, that one of the listeners. Their efforts were invaluable in improving the manuscript. Dungeon Master, DM, and the TSR Logo are trademarks owned by TSR. United States of America. Any. reproduction or other unauthorized use of the material or artwork contained. TSR, Inc. Random. House and its affiliate companies have worldwide distribution rights in the. English language products of TSR, Inc. Distributed to the book. United Kingdom by TSR Ltd. Distributed to the toy and. All Rights Reserved. Foreword. Before we even start, I want to make sure everyone understands one very. This is not AD& D 3rd Edition! We were awfully proud of them when they. We decided. that after six years, it was time for a new look. Both. books are a lot bigger: 2. PHB, 3. 3% more in the DMG. Inside you'll find bigger illustrations. Making the switch turned out. We've. traveled to a multitude of fabulous worlds, from the misty horror of Ravenloft. Al Qadim, and across the burning face of Dark Sun. Now. the endless horizons of Planescape beckon to us, and beyond even that we see spearpoints. Birthright. And, of course. Forgotten Realms. Armor. Modifiers (Optional Rule) The Various. Types of Weapons Impossible. To- Hit Numbers Calculating THAC0 Combat and Encounters The Combat Round What You Can Do. One Round The Combat Sequence Initiative Standard. Initiative Procedure Initiative. Modifiers Group. Initiative (Optional Rule) Individual. Initiative (Optional Rule) Multiple. Attacks and Initiative Spellcasting. Initiative Weapon Speed. Initiative (Optional Rule) Magical. Weapon Speeds Attacking with Two Weapons Movement in Combat Movement in. Melee Movement and. Missile Combat Charging an. Opponent Retreat Attacking Without Killing Punching and. Wrestling Overbearing Weapons in. Non- Lethal Combat Non- Lethal. Combat and Creatures Touch Spells and Combat Missile Weapons in Combat Range Rate of Fire Ability. Modifiers in Missile Combat Firing into a. Melee Taking Cover. Against Missile Fire Grenade- Like. Missiles Types of Grenade- Like. Missiles Special Defenses Parrying (Optional Rule) The Saving Throw Rolling Saving. Throws Saving Throw. Priority Voluntarily. Failing Saving Throws Ability Checks. Saving Throws Modifying. Saving Throws Magic Resistance Effects of. Magic Resistance When Magic. Resistance Applies Successful. Magic Resistance Rolls Turning Undead Evil Priests. Undead Injury and Death Wounds Special Damage Falling Paralysis Energy Drain Poison Treating. Poison Victims Healing Natural Healing Magical Healing Herbalism and. Healing Proficiencies Character Death Death From. Poison Death From. Massive Damage Inescapable. Death Raising the. Dead. Chapter 1. 0: Treasure Treasure Types Magical Items Dividing and Storing Treasure. Chapter 1. 1: Encounters The Surprise Roll Effects of. Surprise Encounter Distance Encounter Options. Chapter 1. 2: NPCs Hirelings Followers Henchmen Player Character. Obligations. Chapter 1. Vision and Light Limits of Vision Light Infravision Using Mirrors. Chapter 1. 4: Time and Movement Movement Jogging and. Running (Optional Rule) Cross- Country. Movement Swimming Holding Your. Breath Climbing Calculating. Success Climbing Rates Types of. Surfaces Actions While. Climbing Climbing Tools Getting Down. Appendix 1: Spell Lists Appendix 2: Notes on Spells Appendix 3: Wizard Spells First- Level Spells Second- Level Spells Third- Level Spells Fourth- Level Spells Fifth- Level Spells Sixth- Level Spells Seventh- Level Spells Eighth- Level Spells Ninth- Level Spells. Appendix 4: Priest Spells First- Level Spells Second- Level Spells Third- Level Spells Fourth- Level Spells Fifth- Level Spells Sixth- Level Spells Seventh- Level Spells. Appendix 5: Wizard Spells by School. Appendix 6: Priest Spells by Sphere. Appendix 7: Spell Index Appendix 8: Compiled Character. Generation Tables (Tables 1- 9, 1. Index Tables Table 1: Strength. Table 2: Dexterity. Table 3: Constitution. Table 4: Intelligence. Table 5: Wisdom. Table 6: Charisma. Table 7: Racial Ability. Requirements. Table 8: Racial Ability. Adjustments. Table 9: Constitution Saving. Throw Bonuses. Table 1. Average Height and. Weight. Table 1. 1: Age. Table 1. 2: Aging Effects. Table 1. 3: Class Ability. Minimums. Table 1. Warrior Experience. Levels. Table 1. 5: Warrior Attacks per. Round. Table 1. 6: Fighter's Followers. Table 1. 7: Paladin Spell. Progression. Table 1. Ranger Abilities. Table 1. 9: Ranger's Followers. Table 2. 0: Wizard Experience. Levels. Table 2. 1: Wizard Spell Progression. Table 2. 2: Wizard Specialist. Requirements. Table 2. Priest Experience. Levels. Table 2. 4: Priest Spell. Progression. Table 2. Rogue Experience. Levels. Table 2. 6: Thieving Skill Base. Scores. Table 2. 7: Thieving Skill Racial. Adjustments. Table 2. Thieving Skill. Dexterity Adjustments. Table 2. 9: Thieving Skill Armor. Adjustments. Table 3. Backstab Damage. Multipliers. Table 3. 1: Thief's Followers. Table 3. 2: Bard Spell. Progression. Table 3. Bard Abilities. Table 3. Proficiency Slots. Table 3. 5: Specialist Attacks. Round. Table 3. 6: Secondary Skills. Table 3. 7: Nonweapon Proficiency. Groups. Table 3. 8: Nonweapon Proficiency. Group Crossovers. Table 3. 9: Tracking Modifiers. Table 4. 0: Movement While. Tracking. Table 4. Weapon Construction. Table 4. 2: Standard Exchange. Rates. Table 4. 3: Initial Character. Funds. Table 4. 4: Equipment. Table 4. 5: Missile Weapon Ranges. Table 4. 6: Armor Class Ratings. Table 4. 7: Character Encumbrance. Table 4. 8: Modified Movement. Rates. Table 4. 9: Carrying Capacities. Animals. Table 5. Stowage Capacity. Table 5. 1: Combat Modifiers. Table 5. 2: Weapon Type vs. Armor. Modifiers. Table 5. 3: Calculated THAC0s. B2. C Content Marketing . Over the past few years, Zappos has been moving toward selling more than shoes (as this magazine clearly shows). Kudos to Zappos for integrating compelling stories with reviews, and the ability to purchase directly from the i. Pad (a great example of content to commerce). Starbucks – My Starbucks Idea. My favorite example from Starbucks is My Starbucks Idea. Since inception, seemingly hundreds of ideas have been reviewed and implemented on the community site. LCBO – Food & Drink Magazine. The LCBO, located in Ontario, Canada, is one of the world’s largest buyers of beverage alcohol, with more than 6. Canada. Vintages is the LCBO’s member- driven publication specifically targeting wine enthusiasts. 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We provide fitness training programs to tennis players of all levels in Sydney and help them improve their results, footwork, speed, agility, core, power and strength. Know about 7 best tennis exercises to improve overall fitness and performance of a tennis player. These tennis training exercises are a part of our unique. The website of the International Tennis. Speed & Agility Training. Although the speed and agility components of fitness are combined when training. Play Better 7 Exercises Every Tennis Player Should Know. Steve Calechman March 16, 2009. The serve can be a wonderful source of free points. The Fitness Partners Tennis Program is just the plan will help you in stages of the game. We can choose the right program to Fit all your tennis needs. Professional tennis players use tennis workouts plans to guide their tennis training. Workout Plan For The Competitive Player. The website of the International Tennis Federation, the world governing body of tennis - information on all aspects of tennis including players, records, rules and. Looking to add a little more power to your shot? Improve your game by trying a strength training program designed specifically for tennis players. This is an exemple about fitness tennis preparation for professional Tennis Player. Recording by DanMasterFilms.com For Info contact [email protected]. A tennis fitness program should be designed to maximize a tennis player’s performance through a proper tennis training routine and is crucial for success. These periods are sequentially arranged and must be followed in their specified order. Building a Solid Tennis Workout Plan. The first phase of any tennis workout plan aims to build a solid foundation of overall body strength. As an athletic endeavour, strength is valuable in order to play the game well. The muscles, ligaments, tendons, bones and joints must be conditioned for the sport. However, tennis places uneven stresses on the body which might lead to postural problems and injuries. This makes it even more vital to train the entire body in order to counteract any tendency to develop imbalances. The following tennis weight training routine is recommended to be performed only twice a week for 6- 8 weeks. This allows ample time for rest and recovery in between sessions. The main targets are the major muscle groups in order to strengthen the whole body. These exercises are done during the off season like in winter. Tennis Workout Plan Using Free Weights. Around 3 sets of 1. Lifts should be smooth and controlled. Either free weights or machine weights can be used. The rest interval between sets should be no more than 9. Before doing the actual work out, start with a 1. Light jogging in place, jumping rope or jumping jacks. Wrist circles. Arm circles . After the work out, another additional 1. Wrist stretches. Tricep stretches. Shoulder stretches. Chest stretches. Lower back stretches. Groin stretches. Quadriceps stretches. Hamstring stretches. Calf stretches. Achilles stretches. These static stretches are held for around 1. The main part of the workout makes use of the exercises usually recommended for this initial phase of your tennis workout plan: Squats or Leg Presses. Bench Presses or Push Ups. Back Extensions on Stability Ball. Lunges. Single Arm Dumbbell Rows. Twisting Crunches. Shoulder Presses. Standing Barbell Curls. Standing Calf Raises. Barbell Upright Rows. The following exercises are specific for the rotator cuff and the forearm and are done not just in the first phase but throughout all phases. Horizontal external rotations. External rotations with knee support. External rotations while lying on one side. Internal rotations. Forearm pronation and supination. Wrist curls. Wrist extensions. Wrist rotations. Grips Tennis Workout Plan to Develop Strength. The second phase of your tennis workout plan aims to develop maximum strength. The exercises used during this period are more intense. If an athlete can train to attain maximum strength, he or she has greater potential to develop more power and muscular endurance. A tennis player should be able to hit the ball just as hard at the end of a long match as he or she has at the beginning. This phase takes just about as long as the first phase (6- 8 weeks). Each exercise is done 2 to 3 times a week. The weight used is 8. Just as in the first phase, a proper warm up and cool down should precede and conclude each work out session. The exercises used during this phase are the following: Barbell Squats or Lying Leg Presses. Bench Presses. Lat Pull Downs. Shoulder Shrugs. Bent Over Rows. Weighted Crunches. In the third phase of a tennis workout plan, the maximum strength that was developed in the previous period is now going to be converted to power and endurance. Exercises are now more tennis specific in the sense that they mimic the movements used in the sport. Tennis Workout Plan: Movement Specific Exercises. These movements are quick and explosive. Simple weight training is not the only component anymore. Instead, plyometric exercises are done additionally. These include jumping exercises and medicine ball throwing exercises. The length of this period is 1- 2 months. Each exercise is done no more than twice a week. Three sets of 8- 1. Like the previous phases, a proper warm up and cool down should bookend each training session. Squat Jumps. Medicine Ball Side Throws. Hurdle Jumps with Sprint. Medicine Ball Over the Back Toss. Box Drill with Rings . Schedule these such that they don. Circuit training makes use of different body weight exercises each being done for one full minute. After each exercise, a 3. After completing all exercises, you are said to have accomplished one circuit. A 2 minute rest is taken between circuits until 2 or 3 circuits have been completed. Needless to say, a proper warm up and cool down should be done before and after a training session. Squat Jumps Push Ups Squat Thrusts Sit Ups with Twist Box Step Ups with High Knee Drive Bench Dips Alternating. Split Squats Alternating Superman exercises . A proper diet can be formulated based on a player. Carbohydrates are the main fuel of the body for physical activity and should be taken before a training session. Complex carbohydrates are best because they are more gradually metabolized and do not get converted to fat as easily as simple sugars. Examples include wheat based bread and cereals, brown rice and pasta. Proper Tennis Diet in a Tennis Workout Plan. Simple sugars can be taken during or right after a training session to replenish depleted stores of carbohydrates. Proteins from eggs, white poultry meat and lean red meat are important in muscle and tissue repair and development. Hence, the ideal time to eat such food is after a training session. Dietary fibre is also important as it improves digestion and contributes to better metabolic regulation. Vitamins and minerals should not be neglected as well. Deficiencies in any of these will result in suboptimal performance due to their effect on the nervous, cardiovascular, musculoskeletal and endocrine systems. Fluids and electrolytes should be replaced during and after your work out. However, be careful not to drink too much while working out. Instead, limit yourself to just a few sips during rest intervals. Drink a lot after the training session. There was a time when even the professional players didn. But today, every serious tennis player must undergo some kind of fitness regimen in order to be successful. 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Windows knows exactly where each fragment is and which is the right order for reading them – that's how you get your file as a whole. File fragmentation occurs when clusters of free disk space get reused over and over again when you delete old files and save new ones. You might wonder why Windows goes through so much hassle whenever you open a file and why it doesn't just put the files as whole blocks. The answer is pretty simple - because the system used by Windows is very space- efficient and doesn't allow a single bit of hard drive space to be wasted. The only downside of putting file fragments all over the drive is that the drive read head needs to do a lot of work to access all fragments of the file. As a result fragmented files can take quite a while to open. Defragging is a simple process when file fragments are put together to speed up file access. File fragments are put together and quality defragmentation utilities also assemble the free space into a single block to prevent future fragmentation. That’s why you should defragment your hard drive on a regular basis. Conflicting opinions about when to defragment your hard drive. How to safely defrag a Mac's hard drive. 3: Hard drives are fastest. As with just about every issue in the world, there are differing opinions about running defragmentation programs on your computer. The main reasons against running defragmenters are. If you defragment your hard drive too often you will shorten its lifespan because of the work it needs to do during a defrag process. Files can become damaged during defragmentation (although this is rare). There are few performance gains to be had if you defragment your hard drive more often than necessary. A middle ground. Both sides of the argument have validity. MyDefrag is licensed as Freeware for Windows (32-bit and 64-bit) operating system / platform from hard drive defrag software without restrictions.So, it is both true that you need to defragment your hard drive, and true that doing so more than necessary could cause problems. Here are some points to keep in mind for optimal hard drive defragmentation. Use a third- party defragmenter, such as Auslogics Disk Defrag, rather than the inbuilt Windows utility. It works much faster and more effectively, shortening the time that your hard drive is working at max capacity. Let your level of computer usage guide the number of times per year that you defragment. If you create and delete a lot of files, if you spend a lot of time online, if you use resource- heavy programs, if you run a database server or a web server, or if you do a lot of video editing you'll need to defragment more often. If you have recently added more than one program, you may need to defrag. Always defragment your hard drive properly - clean up any unwanted files first, run disk cleanup and Scandisk, make a system backup, and THEN run your defragmenter. If you notice your computer becoming sluggish, running your defragmenter program should be one of the first corrective steps you take. Yes, defragmenting is a pain - but because of the way computers are set up, it's a job that won’t be going away any time soon. And there are plenty of tools and techniques you can use to ensure it goes safely, quickly and smoothly. Learn how to speed up your computer by using simple methods from our other articles. Create games on Windows 10. Reach millions of players across phone, PC, and Xbox One. Defraggler - Defragment and Optimize hard disks and individual files for more free space and faster performance. Disk Defragmenter is a utility in Microsoft Windows. This version had the limitation that if the contents of the drive changed. Here is a list of 5 Free software that can easily defragment hard drive and optimize hard drive so that it performs faster. Download free drive defragmentation software. What is the best software program for disk Defrag? Now how could you defrag the hard disk drive without using disk defragment in windows? |
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